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Background: Substantial evidence suggests that consuming 1–2 servings of fish per week, particularly oily fish
(e.g., salmon, herring, sardines) is beneficial for cardiovascular health due to its high n-3 polyunsaturated fatty acid
content. However, there is some concern that the mercury content in fish may increase cardiovascular disease risk,
but this relationship remains unclear.
Methods: The PREDIMED trial included 7477 participants who were at high risk for cardiovascular disease at
baseline. In this study, we evaluated associations between mercury exposure, fish consumption and cardiovascular
disease. We randomly selected 147 of the 288 cases diagnosed with cardiovascular disease during follow-up and
matched them on age and sex to 267 controls. Instrumental neutron activation analysis was used to assess toenail
mercury co...
La transformación digital es parte de cambios profundos en las sociedades
post-industriales que afectan a todas las instituciones sociales. Las empresas
informativas públicas no son excepciones a esta regla. En la primera fase de esta
transición digital, los medios usaban canales digitales para distribuir los contenidos “de siempre” buscando nuevas fuentes de ingresos (Picard, 2014). Los resultados fueron, cuando menos, decepcionantes. Comienza ahora una etapa en que las empresas necesitan complementar el modelo que reunía grandes audiencias y
anunciantes con modelos que faciliten el pago directo y las suscripciones.
Apenas estamos empezando a entender el impacto en la gestión de tendencias como la participación, la movilidad o la “multimedialidad. En los medios
digitales, la participación de las audiencias debería darse por supu...
The Spanish Crown’s Tobacco Tax Monopoly vas decreed only for the kingdom of Castile in 1936. Due to its acknowledged performance. Spanish rulers tried to set it up wherever politically possible. After the War of Succession, it was established in the kingdoms of Aragon, so those kingdoms lost their political autonomy. Basque provinces and Navarre succeeded to preserve their special political status, and the Spanish Government could not put into service the general Tobacco Tax Monopoly there and had to negotiate solutions in order to not damage the general Monopoly. Finally, in the context of the Bourbonic reforms in America, the Tobacco Tax Monopoly was gradually introduced in every territory of the Spanish Indies.
En el sexto episodio de la primera temporada, mientras un grupo especial de policías afina el sistema de escuchas para captar los movimientos de los narcotraficantes en Baltimore, el veterano investigador Lester Freamon le comenta al joven Roland Pryzbylewski: «Estamos construyendo algo aquí, detective. Lo estamos construyendo desde cero. Todas las piezas importan». La frase actúa como metacomentario de la innovadora y arriesgada estrategia narrativa que empleó The Wire. Creada por Ed Burns y David Simon, esta tragedia sobre la ciudad contemporánea cumplía los postulados del famoso lema promocional «It’s not TV; it’s HBO». Se trataba de una propuesta diferente a cualquier cosa que hubiera intentado el medio televisivo antes: una novela audiovisual, de aire naturalista, que se desplegaba durante más de sesenta horas; una historia que se...
Prospective studies assessing the association between fibre intake or fibre-rich food consumption and the risk of CVD have often been limited
by baseline assessment of diet. Thus far, no study has used yearly repeated measurements of dietary changes during follow-up. Moreover,
previous studies included healthy and selected participants who did not represent subjects at high cardiovascular risk. We used yearly
repeated measurements of diet to investigate the association between fibre intake and CVD in a Mediterranean cohort of elderly adults at
high cardiovascular risk. We followed-up 7216 men (55–80 years) and women (60–80 years) initially free of CVD for up to 7 years in the
PREvención con DIeta MEDiterránea study (registered as ISRCTN35739639). A 137-item validated FFQ was repeated yearly to assess diet. The
primary end point, ...
Glutamate metabolism may play a role in the pathophysiology of cardiometabolic disorders. However, there is
limited evidence of an association between glutamate-related metabolites and, moreover, changes in these metabolites, and risk of
cardiovascular disease (CVD).
Methods and Results-—Plasma levels of glutamate and glutamine were measured at baseline and 1-year follow-up in a case-cohort
study including 980 participants (mean age 68 years; 46% male) from the PREvenci on con DIeta MEDiterr anea (PREDIMED)
randomized trial, which assessed a Mediterranean diet intervention in the primary prevention of CVD. During median 4.8 years of
follow-up, there were 229 incident CVD events (nonfatal stroke, nonfatal myocardial infarction, or CVD death). In fully adjusted
models, per 1-SD, baseline glutamate was associated with 43% (95% CI: ...
