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This is the author accepted manuscript. It is currently under an indefinite embargo pending publication by Informa Law.
This is the author accepted manuscript. It is currently under an indefinite embargo pending publication by Informa Law.
We have adapted two widely used aphasia tests, the Boston Diagnostic Aphasia Examination (BDAE) and the Boston Naming Test (BNT), to the Finnish language. The BDAE is the first extensive standardized aphasia test battery that will be published in Finnish. The test adaptations as well as reliability and validity information of the Finnish BDAE version are described. The Finnish versions of both BDAE and BNT are expected to gain widespread use among speech therapists and neuropsychologists working with Finnish-speaking subjects. © 1993 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.
Epigenetics is the process by which patterns of gene expression are modified in a mitotically heritable manner. However, these epigenetic variations are not attributable to changes in the primary nucleotide sequence within DNA. In this review, the emerging field of epigenetics is introduced and the potential role it may have in the manifestation of common ocular disease is explored. Given our current understanding of the genetic, environmental and phenotypic profiles, it is probable that stochastic epigenetic effects have an important role in the pathogenesis of age-related macular degeneration, glaucoma, cataract and myopia. The ability to profile individuals at an epigenetic level offers a novel means to intimately dissect gene–environment interactions.
A theory-guided instrument for examining prescription stimulant misuse in the college population was developed and its psychometric properties were evaluated from 2011-2012 at one Pacific Northwest (United States) university. Study methods included instrument development, assessment by five health and measurement professionals, group interviews with six college students, a test-retest pilot study, and a paper-based, in-classroom, campus study using one-stage cluster sampling (N = 520 students, 20 classrooms, eligible student response rate = 96.30%). The instrument demonstrated reliability (i.e. internal consistency and stability) and validity (i.e. face, content, and predictive). Limitations and implications are discussed.
This study explored the therapeutic effect of antidepressants in Parkinson's disease (PD) using a meta-analysis. Altogether, 24 placebo-controlled trials qualified for inclusion and revealed that tricyclic antidepressants (TCAs) had a greater antidepressant effect relative to selective serotonin reuptake inhibitors (SSRIs), Qb(1) = 8.87, p <.01, and the mono-amine-oxidase inhibitor, selegiline, Qb(1) = 7.90, p <.01. Whereas TCAs produced a significant side effect profile (odds ratio = 3.07), adverse events were negligible with SSRIs (odds ratio = 1.83) and selegeline (odds ratio = 1.63). Antidepressants can be beneficial for patients with PD. However, the choice of antidepressants needs to take depressive symptomatologies into account while monitoring side effects. Copyright © 2008 Informa Healthcare USA, Inc.
Primary Objective: To describe the processes involved with developing and implementing a physical activity based health promotion program for people with a brain injury, summarize previous health promotion research efforts, and provide an actual example of a program entitled P.A.C.E, a “Physical Activity Centred Education” program. Reasoning Behind literature Selection: Brain injury is serious public health issue due to the incidence, complexity, and high health care costs. Health promotion programmes that incorporate physical activity have been shown to improve the health of people with a disability. However, if programmes are to be successful they have to be appropriately designed otherwise individuals will not adopt and maintain the desired health behaviours. Main outcomes and results: Readers will have an understanding of ...
A promising formulation of glipizide comprising compression of four-layer coated beads into tablets which has advantages of providing a lag time (~ 2 hours) before drug release, retaining sustained-release characteristics, and providing approximately zero-order drug release, with drug release nearly independent of paddle speeds of 50 and 100 rpm during dissolution testing while keeping the benefits of mulitparticular dosage forms. The tablets contain beads with four layers: the drug layer of 71.25 g of sugar beads overcoated with 2.5 g of glipizide and 3.75 g of solid ethylcellulose (Surelease®); the hardening layer of 5 g of hypromellose (HPMC); the controlled release layer of 7.5 g of ratio solid content of Surelease®:lactose = 100:7; and outmost layer of 20 g of lactose:sodium starch glycolate (Explotab®) = 2:1. Then beads were comp...